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Tanuki

(14,926 posts)
Tue May 19, 2020, 01:37 PM May 2020

Troubling news re: the Oxford Covid vaccine trial

https://www.forbes.com/sites/williamhaseltine/2020/05/16/did-the-oxford-covid-vaccine-work-in-monkeys-not-really

"The day after data appeared from the vaccine maker Sinovac showed complete protection of rhesus monkeys by their vaccine candidate (whole inactivated SARS-CoV-2 virus particles), scientists from the Jenner Institute in Oxford issued a press release announcing that their vaccine (an adenovirus vector based vaccine that carried the SARS-CoV-2 spike protein) worked to protect rhesus monkeys and that they were moving forward with large scale human safety trials. At the time, the substantiating data was not available. Now it is, in the form of a May 13 BioRxiv preprint. Does the data support the claim?

Not really. All of the vaccinated monkeys treated with the Oxford vaccine became infected when challenged, as judged by recovery of virus genomic RNA from nasal secretions. There was no difference in the amount of viral RNA detected from this site in the vaccinated monkeys as compared to the unvaccinated animals. Which is to say, all vaccinated animals were infected. This observation is in marked contrast to the results reported from Sinovac trial. At the highest dose studied, no virus was recovered from vaccinated monkeys from the throat, lung, or rectum of the vaccinated animals. 
.....

The vaccinated and control animals were followed for clinical signs of infection for seven days post infection. One clinical sign of infection in rhesus monkeys is breathing rate. Monkeys ill from SARS-CoV-2 infection breathe more rapidly than normal. By this measure 3 of the 6 vaccinated monkeys were clinically ill, the remaining three were not clinically distinguishable from the unvaccinated animals."...(more)
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Troubling news re: the Oxford Covid vaccine trial (Original Post) Tanuki May 2020 OP
WHOA . .. Iliyah May 2020 #1
The Oxford team was arrogant in their pronouncements. RhodeIslandOne May 2020 #2
Let us hope. Delphinus May 2020 #3
Yes. I though so too. Dream Girl May 2020 #4
They sure were. That leaves Moderna as the lead in further ahead in vaccine development still_one May 2020 #5
How so? Disaffected May 2020 #7
Because they will be starting phase 2 in June as I understand it still_one May 2020 #8
But might provide some protection crimycarny May 2020 #6
That announcement was awful quick... Wounded Bear May 2020 #9

crimycarny

(1,351 posts)
6. But might provide some protection
Tue May 19, 2020, 03:03 PM
May 2020

Saw this the other day. While potentiality disappointing I’m still hopeful as the article said the vaccine might provide some protection, even if not 100%. Much like the flu vaccine that averages a little under 40%. If it can provide at least some protection it might buy more time until the Moderna vaccine makes it past all hurdles (fingers crossed!!!).

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