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Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsTroubling news re: the Oxford Covid vaccine trial
https://www.forbes.com/sites/williamhaseltine/2020/05/16/did-the-oxford-covid-vaccine-work-in-monkeys-not-really"The day after data appeared from the vaccine maker Sinovac showed complete protection of rhesus monkeys by their vaccine candidate (whole inactivated SARS-CoV-2 virus particles), scientists from the Jenner Institute in Oxford issued a press release announcing that their vaccine (an adenovirus vector based vaccine that carried the SARS-CoV-2 spike protein) worked to protect rhesus monkeys and that they were moving forward with large scale human safety trials. At the time, the substantiating data was not available. Now it is, in the form of a May 13 BioRxiv preprint. Does the data support the claim?
Not really. All of the vaccinated monkeys treated with the Oxford vaccine became infected when challenged, as judged by recovery of virus genomic RNA from nasal secretions. There was no difference in the amount of viral RNA detected from this site in the vaccinated monkeys as compared to the unvaccinated animals. Which is to say, all vaccinated animals were infected. This observation is in marked contrast to the results reported from Sinovac trial. At the highest dose studied, no virus was recovered from vaccinated monkeys from the throat, lung, or rectum of the vaccinated animals.
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The vaccinated and control animals were followed for clinical signs of infection for seven days post infection. One clinical sign of infection in rhesus monkeys is breathing rate. Monkeys ill from SARS-CoV-2 infection breathe more rapidly than normal. By this measure 3 of the 6 vaccinated monkeys were clinically ill, the remaining three were not clinically distinguishable from the unvaccinated animals."...(more)
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Troubling news re: the Oxford Covid vaccine trial (Original Post)
Tanuki
May 2020
OP
They sure were. That leaves Moderna as the lead in further ahead in vaccine development
still_one
May 2020
#5
Iliyah
(25,111 posts)1. WHOA . ..
RhodeIslandOne
(5,042 posts)2. The Oxford team was arrogant in their pronouncements.
That will teach them some humility.
Delphinus
(11,845 posts)3. Let us hope.
Dream Girl
(5,111 posts)4. Yes. I though so too.
still_one
(92,479 posts)5. They sure were. That leaves Moderna as the lead in further ahead in vaccine development
Disaffected
(4,571 posts)7. How so?
Are Sinovac and Moderna doing the same vaccine?
still_one
(92,479 posts)8. Because they will be starting phase 2 in June as I understand it
crimycarny
(1,351 posts)6. But might provide some protection
Saw this the other day. While potentiality disappointing Im still hopeful as the article said the vaccine might provide some protection, even if not 100%. Much like the flu vaccine that averages a little under 40%. If it can provide at least some protection it might buy more time until the Moderna vaccine makes it past all hurdles (fingers crossed!!!).
Wounded Bear
(58,755 posts)9. That announcement was awful quick...
not surprising that the rosy prediction might be a bit premature.