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NaturalHigh

(12,778 posts)
Sun May 31, 2015, 08:10 PM May 2015

Altered herpes virus used to fight melanoma

Shari Wells vividly recalls sitting with doctors at the University of Louisville's James Graham Brown Cancer Center and learning that her melanoma was so dangerous and advanced that she likely had less than six months to live.

But then came a clinical trial that she calls "my lifesaver," in which a modified version of the herpes virus is used to fight the deadliest form of skin cancer, which strikes 70,000 Americans a year, kills 9,000, and is on the rise.

The treatment "saved my life," said Wells, 56, of Ashland, Ky., whose cancer went into remission. "I was never so thankful in my whole life than for that medicine. Without it, I would be dead."

Herpes, known for cold sores and misery, is being made into a weapon, the latest example of turning one bane of humanity against another by using viruses to target cancer.


http://www.courier-journal.com/story/life/wellness/health/2015/05/29/altered-herpes-virus-used-fight-melanoma/28150477/

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Altered herpes virus used to fight melanoma (Original Post) NaturalHigh May 2015 OP
Amazing, thanks for posting this news. appalachiablue May 2015 #1
My pleasure. NaturalHigh May 2015 #3
That's a very interesting treatment: Buzz Clik May 2015 #2
Excellent. 840high May 2015 #4
knr n/t slipslidingaway May 2015 #5
Advances are being made in this field ... slipslidingaway Jun 2015 #6
Thanks. NaturalHigh Jun 2015 #7
Me too!!! slipslidingaway Jun 2015 #8
 

Buzz Clik

(38,437 posts)
2. That's a very interesting treatment:
Sun May 31, 2015, 08:33 PM
May 2015
A study involving 436 late-stage melanoma patients at 64 centers around the globe, published in the current issue of the Journal of Clinical Oncology, shows that those injected with a genetically-modified version of the herpes simplex virus known as T-VEC responded better than a control group...

..Over the years, scientists have explored altering various viruses, including measles and polio, to combat several types of cancer, including brain tumors, breast cancers and others. A 2013 review in the journal Molecular Cancer concluded that cancer-fighting viruses armed with genes that stimulate the immune system, "are potent therapeutic cancer vaccines." Such viruses, including T-VEC, will be discussed at the annual meeting of the American Society of Clinical Oncology, which runs through June 2.

T-VEC, a product of California-based biotechnology company Amgen, is made by removing the gene that causes herpes from the virus and inserting a different gene that revs up the immune system, said researcher Jason Chesney of the University of Louisville, deputy director of the Brown Cancer Center and a co-author on the study. The virus enters cancer cells and "blows them up," he said, at the same time stimulating the body to fight the cancer.

slipslidingaway

(21,210 posts)
6. Advances are being made in this field ...
Mon Jun 1, 2015, 12:05 AM
Jun 2015

first I remember reading was the trial at the University of Pennsylvania with acute lymphocytic leukemia patients a few years. This year when my husband relapsed after a bone marrow transplant for acute myeloid leukemia, I met two patients who were given reengineered cells for acute lymphocytic leukemia. One patient we met again as an outpatient and he was doing well, the other patient was transferred to the ICU and not sure of the outcome. You meet so many people while in the hospital, but do not always keep in touch. A couple of months later we met another person at Hope Lodge who had undergone a similar treatment for lymphoma, once at the NIH and another at U Penn, he is currently receiving a third treatment at Sloan and we will see him later this week after appointments. Hoping the third time is a charm!

This is the first I've heard of the treatment being used for melanoma, I know that they are working on it for my husband's disease as well.

Thanks for posting

slipslidingaway

(21,210 posts)
8. Me too!!!
Mon Jun 1, 2015, 12:34 AM
Jun 2015

It has helped some already, for how long, that remains to be seen. Still we have to have hope

The person I mentioned that has received this treatment twice, once they used the HIV as a means to combat his disease. He subsequently tested positive for HIV, but later on they determined it was a false/positive result for HIV. The doc at U Penn took additional samples as he was journaling the progress. We'll see him on Friday at Sloan as he undergoes a similar therapy for the third time.

We live in interesting times, although I wish I was not so interested in the topic!

Appreciate you bringing this to the GD forum

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