US Senate seats up for re-election in 2022 that Democrats are likely to lose, hold on and pick up.

Lose
NH(Hassan-D) if Sununu-R or Ayotte-R are the GOP Nominee.
AZ(Kelly-D) if Ducey-R, Brmovich-R, or Yee-R are the GOP Nominee.
NV(Cortez Masto-D) if Sandoval-R is the GOP Nominee.
Hold on
CA(VACANT Harris-D)36
VT(Leahy-D or Donovan-D)37
NY(Schumer-D)38
HI(Schatz-D)39
MD(Van Hollen-D)40
CT(Blumenthal-D)41
IL(Duckworth-D)42
OR(Wyden-D)43
WA(Murray-D)44
CO(Bennet-D)45
Pick up
PA(OPEN Toomey-R) Fetterman-D or Shapiro-D/46
WI(Johnson-R)Barnes-D, Kaul-D, or Godlewski-D/47
NC(OPEN Burr-R) Jackson-D/48

Democrats need to win and hold onto both of the GA US Senate seats or AZ,NV, or NH in order to regain control of the US Senate.