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RKP5637

(67,112 posts)
Wed Feb 29, 2012, 09:49 AM Feb 2012

New Article - Sleeping Pills Called 'as Risky as Cigarettes'

I posted about this yesterday, this is a new article now on WebMD which has more information. Just passing this along FYI, because it has a lot more detail. Now that I see it on WebMD too, at least IMO, it seems to have more validity, or at least to take note of for more information as it becomes available. I do hate it when studies suddenly appear like this invoking a panic of sorts among the population ... and then often later we find the validity of the study in question. Well, anyway, here it is ...

See >>> http://www.webmd.com/sleep-disorders/news/20120227/sleeping-pills-called-as-risky-as-cigarettes

"WebMD Health News
Reviewed by Michael W. Smith, MD

Feb. 27, 2012 -- A provocative new study finds that people who take prescription sleeping pills -- even once in a while -- have a higher death risk than non-users.

The top third of sleeping-pill users had a 5.3-fold higher death risk. They also had a 35% higher risk of cancer, the study found.

"We are not certain. But it looks like sleeping pills could be as risky as smoking cigarettes. It looks much more dangerous to take these pills than to treat insomnia another way," study leader Daniel F. Kripke, MD, tells WebMD.

The sleeping pills in question are known as hypnotics. They include newer drugs such as zolpidem (the best known brand name is Ambien) as well as older drugs such as temazepam (the best known brand name is Restoril).

Hypnotic sleeping pills actually cause a person to fall asleep. This sets them apart from other sleeping aids, such as the supplement melatonin, which promote sleep through relaxation. Other sleep drugs described as hypnotics by Kripke and colleagues include eszopiclone (Lunesta), zaleplon (Sonata), triazolam (Halcion), flurazepam (Dalmane), barbiturates, and older antihistamines such as diphenhydramine."

<snip>

"Most of the people in the Kripke study were taking Ambien or Restoril. Sanofi-Aventis, the maker of Ambien, notes that the Kripke study has a number of shortcomings.

"Ambien has more than 17 years of real-world experience and is safe and effective when prescribed and taken according to its labeling," Sanofi says in a statement sent to WebMD. "Ambien should be prescribed in strict adherence to its labeling and patients should take their medication as prescribed. The Ambien labeling carries specific warnings against driving and against intake of alcohol together with Ambien.""

More at >>> http://www.webmd.com/sleep-disorders/news/20120227/sleeping-pills-called-as-risky-as-cigarettes

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Response to RKP5637 (Original post)

thucythucy

(8,136 posts)
2. The article says
Wed Feb 29, 2012, 11:07 AM
Feb 2012

the study "tried to control" for sleep disturbance as the link to cancer, as opposed to sleeping meds.

I'd have to read the study to see how they did this. The main question, though, is whether the control group was people who had similar sleep issues NOT taking these meds, as opposed to people in the general population or people with less severe sleep disturbance. If they DID control for sleep disturbance, then this is a very troubling study indeed. The problem would be making a proper diagnosis of the underlying sleep issue, which is terrifically difficult. For instance, people with disturbed sleep due to depression are different from people with disturbed sleep due to fibromyalgia or other physical pain issues. For the study to be truly valid, it would need to control for all these variables.

Note: I self deleted because my original post assumed they hadn't controlled for sleep disturbance. Reading the entire article I see at least some attempt to do so was made. My bad.

Warpy

(111,470 posts)
6. This is a hysterical headline from a bad study
Wed Feb 29, 2012, 05:40 PM
Feb 2012

The study was a bad one because it failed to use typically sleep deprived people as a control and it also failed to differentiate between psychiatric use of these drugs versus their use as simple sleep aids.

Sleep deprivation is likely the reason for the increased deaths among sleeping pill users, even those who typically tough it out and only resort to the pills a few times a year. Of course the death rate is going to be higher, if only for the effects of chronic sleep deprivation contributing to a global range of illnesses, not to mention inattentiveness and proneness to accident.

Even the bottom line of the study was that the number of deaths overall was very small.

As dangerous as cigarettes? This headline writer needs to be sued for malpractice.

RKP5637

(67,112 posts)
7. Somehow, those making studies like this and then releasing information need
Wed Feb 29, 2012, 06:39 PM
Feb 2012

to be held accountable for their actions if the study is found to be flawed due to hysterical researches, premature information, profit motivations, etc., etc. There seems to be too much of this going around now. Now it seems the only control point is peer review.

Tumbulu

(6,292 posts)
10. agree
Fri Mar 2, 2012, 04:36 PM
Mar 2012

as it is most likely the sleep deprivation and not the remedy for it that is the source of the increased deaths.

 

CanSocDem

(3,286 posts)
8. Natural sleep is the great Cure-All...
Thu Mar 1, 2012, 11:36 AM
Mar 2012


...so it would follow that 'unnatural' sleep, such as drug induced loss of conciousness, would detract from this quality.

Of course, in the fast paced corporate world, having enough sleep to avoid nodding off in mid-sentence, is usually enough.

.

RKP5637

(67,112 posts)
9. Yeah, well said, "... in the fast paced corporate world, having enough sleep to avoid nodding off
Thu Mar 1, 2012, 11:39 AM
Mar 2012

in mid-sentence, is usually enough."

McCamy Taylor

(19,240 posts)
11. Should be "Sleep apnea" as risky as cigarettes.
Fri Mar 2, 2012, 11:57 PM
Mar 2012

Association is not causality. People with sleep disorders such as OSA take sleeping pills. OSA causes diabetes, heart attack, stroke and premature death. Sleeping pills mask the sypmptoms of OSA and can make hypoxia worse. But the sleeping pill is not the cause. It is the breathing disorder.

Unfortunately, it is cheap to ask folks "Do you take sleeping pills?" and it is expensive ($2000) to do a sleep study. So we get "research" like this---which is as valuable as saying "Because men who buy large shoe sizes are tall, buying large shoes helps you grow."

Can't wait for the TV ads "Do you or someone you know take sleeping pills? Have you had a stroke or heart attack? Call this number to find out how you can get compensation..."

RKP5637

(67,112 posts)
12. All very good points! My feeling is this is one of those studies that as it unfolds we will
Sat Mar 3, 2012, 01:08 AM
Mar 2012

find a lot of detail that comes out in the wash, so to say. Yeah, as you say, next will be the legal hounds moving in to try to make a buck.

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