Health

xchrom

(108,903 posts) Sun Jun 17, 2012, 09:00 AM Jun 2012

Artificial immune system gives baby vaccines a booster

http://www.newscientist.com/article/mg21428664.500-artificial-immune-system-gives-baby-vaccines-a-booster.html

***SNIP

To improve the development of vaccines for newborns, Levy, Sanchez-Schmitz and their colleagues have created a new way of modelling the newborn immune system.

The team first took blood from human umbilical veins and used it to culture two types of cells: those that make up blood-vessel walls and white blood cells, which are key drivers of the immune response. Team member Chad Stevens, also at the Boston Children's Hospital, was able to grow these cells in the collagen matrix that in the body forms their physical and biochemical support system - something that has not been done before - by finding the ideal conditions in which to mature the collagen. The system is topped off with newborn plasma - the liquid component of blood.

The model is the first artificial immune system to consist of entirely human components,and acts in a similar way to a real newborn's immune system, says Levy. His team watched as white blood cells passed through blood-vessel-wall cells and transformed into dendritic cells - which recognise foreign material and flag it as a target for other immune cells - just as they would when they come across a pathogen in the body.

In their latest experiment, the team found that the model responded to the BCG vaccine for tuberculosis in the same way that newborns have in clinical trials. "A single dose of BCG vaccine not only activates dendritic cells but enhances their ability to drive white-blood-cell proliferation and the generation of signalling molecules," just as it would in a newborn, says Levy. What's more, the model produced the same ratio of cells, says Sanchez-Schmitz, who presented the work at the American Association of Immunologists' annual meeting in Boston earlier this month.

9 replies

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Artificial immune system gives baby vaccines a booster (Original Post) xchrom Jun 2012 OP

Wait till Monsanto hears someone is beating them to the punch. postulater Jun 2012 #1

"He and Sanchez-Schmitz are already using the model to develop new adjuvants..." mzmolly Jun 2012 #2

Adjuvants have been safety TZ Jun 2012 #3

Please share the studies you speak of. The mouse/rat studies mzmolly Jun 2012 #4

Go to ANY ANY ANY Clinical trial TZ Jun 2012 #6

The studies have not been "debunked" and Mr. Saul mzmolly Jun 2012 #9

A newer study, noted at the wiki link mzmolly Jun 2012 #5

Uh Lupus TZ Jun 2012 #7

Read the link mzmolly Jun 2012 #8

postulater

(5,075 posts)

1. Wait till Monsanto hears someone is beating them to the punch.

Reply to xchrom (Original post)

Sun Jun 17, 2012, 11:06 AM

Jun 2012

mzmolly

(51,019 posts)

2. "He and Sanchez-Schmitz are already using the model to develop new adjuvants..."

Reply to xchrom (Original post)

Thu Jun 21, 2012, 11:51 AM

Jun 2012

Woo hoo!

"Aluminum adjuvants have caused motor neuron death in mice[37] when injected directly onto the spine at the scruff of the neck, and oil-water suspensions have been reported to increase the risk of autoimmune disease in mice.[38] Squalene has caused rheumatoid arthritis in rats already prone to arthritis.[39]

In cats, vaccinations have been linked to sarcomas, at a rate of between 1 and 10 per 10,000 injections. No specific types of vaccines, manufacturers or factors have been associated with sarcomas."[40]

Of course ... "Aluminium salts used in many human vaccines are generally regarded as safe.[36]"

http://en.wikipedia.org/wiki/Immunologic_adjuvant

TZ

(42,998 posts)

3. Adjuvants have been safety

Reply to mzmolly (Reply #2)

Wed Jun 27, 2012, 11:01 AM

Jun 2012

tested in THOUSANDS OF TOX STUDIES IN MICE AND RATS before they are EVER put into humans. But what do I know. I worked at NIH on vaccine development and WORKED ON THOSE SAME GODDAMN TOX STUDIES. But of course NIH knows less than Wikipedia.

mzmolly

(51,019 posts)

4. Please share the studies you speak of. The mouse/rat studies

Reply to TZ (Reply #3)

Wed Jun 27, 2012, 01:53 PM

Jun 2012

that I'm familiar with, concern me. This one, in particular.

http://www.ncbi.nlm.nih.gov/pubmed/17114826

And this one.

http://www.ncbi.nlm.nih.gov/pubmed/19740540

A newer one of possible interest.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056430/?tool=pubmed

TZ

(42,998 posts)

6. Go to ANY ANY ANY Clinical trial

Reply to mzmolly (Reply #4)

Wed Jun 27, 2012, 02:50 PM

Jun 2012

On NIH or CDC or WHO data. You do know that all vaccines have at least 5-10 years of TOX STUDIES on mice and rats using the vaccine with adjuvants

Oh and those studies have been thoroughly debunked. Gulf War syndrome is thought to be a mix of pesticides and parasites in the desert.
BTW you seem to not understand biology enough to understand that adjuvants are attached to the antibody and are OUT of the system in two weeks via the spleen. They DO NOT linger. Thats why some vaccines need boosters.
BTW, in my 7 years here you cite the same idiotic debunked studies over and over again. But hey, I worked for one of the world's foremost Vaccine experts. Find me a paper with Dr. Allan Saul's name on it that shows aluminum adjuvants are dangerous and you might have a case. He has literally hundreds of papers. Get to work.
By the way aluminum and aluminum adjuvants are about as chemically the same as Chlorine vs Sodium Chloride (table salt). You know about as much science as a 12 year old . Seriously. Stop posting the same garbage.

mzmolly

(51,019 posts)

9. The studies have not been "debunked" and Mr. Saul

Reply to TZ (Reply #6)

Wed Jun 27, 2012, 03:41 PM

Jun 2012

Last edited Wed Jun 27, 2012, 09:41 PM - Edit history (1)

works for Novartis.

The childish insults you hurl, are not the studies I requested. Again, where are the studies on adjuvants alone, that you said existed above?

"aluminum and aluminum adjuvants are about as chemically the same as" ... you should sound more "sciencey" given your supposed expertise.

The scientists who conducted the studies I've noted above, are not 12. Seriously, stop posting the same garbage.

TZ must be a new user name, as you're unfamiliar to me.

mzmolly

(51,019 posts)

5. A newer study, noted at the wiki link

Reply to TZ (Reply #3)

Wed Jun 27, 2012, 01:58 PM

Jun 2012

you don't care for.

"Induction of lupus autoantibodies by adjuvants"

http://www.sciencedirect.com/science/article/pii/S0896841103000830

One thing I like about wiki, is that I can check the references.

TZ

(42,998 posts)

7. Uh Lupus

Reply to mzmolly (Reply #5)

Wed Jun 27, 2012, 02:53 PM

Jun 2012

patients DON"T GET VACCINES because THEY HAVE AN AUTOIMMUNE DISORDER. DUH. I have a sister with Lupus. Vaccines don't give you lupus. BUt people with Lupus can get sick because of anti-vaxxers like you. My sister can't get a pertussis vaccine. But she got Pertussis from a bunch of unvaccinated kids at her daughter's school who are influenced by WIKI idiots like you. But what do I know, clearly WIKI> NIH. WIKI IS THE SHITTIEST SCIENCE SOURCE ON THE WEB.
But hay, enjoy your pro-disease lobby. Cause thats what you are.
Geeze five years and you still don't understand biology thats taught in HS.

mzmolly

(51,019 posts)

8. Read the link

Reply to TZ (Reply #7)

Wed Jun 27, 2012, 03:36 PM

Jun 2012

again because "you still don't understand" the study implications.

I'll let your "pro-disease" assertion speak to the fact that you've run out of anything productive to say.

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