NCBI study of the efficacy of seawater nasal wash for Covid symptoms and URI [View all]

https://www.ncbi.nlm.nih.gov/research/coronavirus/publication/38376591


Seawater nasal wash to reduce symptom duration and viral load in COVID-19 and upper respiratory tract infections: a randomized controlled multicenter trial.
de Gabory, Ludovic; Vallet, Sophie; Naelten, Gaelle; Raherison-Semjen, Chantal Eur Arch Otorhinolaryngol
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PURPOSE: The objective was to assess the efficacy of seawater nasal wash on symptom duration, intranasal viral load, household transmission in COVID-19 and URTIs. METHODS: This prospective, randomized, controlled, multicentric, parallel study included 355 mild/moderate COVID-19 and URTI adults with rhinologic symptoms /= 1.5log10 copies/10000 cells at Day 5: 88.9% vs 62.5%, p = 0.0456). In the active group, a lower percentage of SARS-CoV-2 positive household contacts (0-10.7%) was reported vs controls (3.2-16.1%) among subjects with Delta variant (p = 0.0413). CONCLUSION: This trial showed the efficacy and safety of seawater nasal wash in COVID-19 and URTIs. TRIAL REGISTRATION: Trial registry ClinicalTrials.gov: NCT04916639. Registration date: 04.06.2021.
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