Reply #23: MS Publisher has Side Fold Car/Top Fold Card Options for 4/page [View All]

One chooses New/Blank Publications/Side (Top) Fold Card and four pages are inserted into the layout. To make it double-sided, insert another 4 sheets. You put whatever on each page, then, using Adobe Acrobat, print it to a file (could probably use something else but I like PDF's). You end up with a file that prints 2 8 1/x11 sheets, each sheet with 4 pages on it. the top two inserted pages face up, the bottom two face down, so that when folded-

Granted, it's not 6 pages per sheet, but the 4 pages is extremely easy to do, and one could always, on the first page, put in two text areas,instead of one, (or even four areas) so that a title page of some sort faces up, iF the whole thing is refolded to be more pages.
Example

when printing, even on a home printer, all you'd have to do is print, say, 10 copies of one page, then turn those pages over in the printer and print the 2nd page on the other side.