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Reply #4: Can't you get gross chromosomal rearrangements from broken DNA? [View All]

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Sufi Marmot

(1000+ posts) Send PM | Profile | Ignore

Fri Dec-24-04 12:56 PM
Response to Reply #3

4. Can't you get gross chromosomal rearrangements from broken DNA?

Some leukemias are caused by translocations that fuse together two disparate gene products into an oncogene. I'm not saying this is going to be a common event from regular cell phone use, but when cells suffer double strand breaks, they try to repair them, and the results aren't always ideal. There are mechanisms of DNA repair which don't involve copying from the other chromosome (non-homolgous end-joining, for instance), so genetic information can be lost or altered. In multicellular eukaryotes, death is the best thing that can happen when a cell suffers a double strand break, IMHO.

-SM

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