1. Diet (what kind of food you consume and how much) 2. Genetics (Some people have high metabolism rates; some don't) 3. Lifestyle 4. And apparently now bateriological determinants within the stomach/intestines
The key to managing one's weight will likely have to take into account all those factors and potentially more. Right now, there appears to be no solution for the 4th factor listed or even the 2nd one listed, but that shouldn't stop one from taking steps to counter 1 and 3 if not for the goal of losing weight than for the goal of maintaining cardiovascular health.
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