Source:
Daily Mirror (UK)Mike Swain, Science Editor.
It is a scientific milestone as great as the first flight, a medical breakthrough to rival antibiotics.
In simultaneous announcements yesterday scientists in Japan and America said they had discovered how to take an ordinary skin cell - and transform it into any other kind of human body cell.
It means that in the not-very distant future doctors will take a scraping of your skin and grow you a new heart or liver. Or special insulin-producing cells to end the misery of diabetes.
Or develop any number of treatments for any number of life-threatening or debilitating conditions.
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It means scientists are on the way to creating your very own body repair kit. And in the process it will eliminate the need for controversial embryo cloning.
The technique is simple in theory, complex in practice."
"Its potential for treating diseases such as Parkinson's, which is caused by the loss of brain cells, is incalculable.
In theory it could also one day spell the end of transplant surgery as scientists would be able to regenerate damaged parts of the body without the need for donated organs.
Leading British stem cell researcher Professor Ian Wilmut of the University of Edinburgh, who created Dolly the sheep, has already announced that he is abandoning cloning in favour of the new technique.
"This is extremely exciting," he said. "We can now envisage a time when a simple approach can be take it all the way back and then turn it into any kind of body cell. It is quite incredible what we can now do.
"It is relatively easy to grow an entire plant from a small cutting, something that has seemed inconceivable in humans.
"Yet this study brings us tantalisingly close to using skin cells to grow many different types of human tissues.
"Normally when you grow skin cells in a dish, they just make skin cells.
"But they have re-programmed them into embryonic-like stem cells with the potential of turning into any different cell types." There is still a long way to go - only 10 cell clones were obtained from 50,000 skin cells. But in the Japanese laboratory clumps of skin cells treated to become heart cells started to pulse - just as heart cells cause the heart to beat.
"It is at a very early stage. But by using different genes we will hope to gain a good insight into how this magic takes place," Professor Surani said.
"What is clearly possible is that we can make cells from any individual with a simple skin biopsy.
"Or we can take cells from someone with a history of heart disease and study them to see how the heart cells are developing.
"Then we could develop targeted drugs to treat them." One of the most exciting aspects of the discovery is the simple fact that since the new cells or even new organ come from your own body there is very little likelihood of rejection.
Japan's Professor Yamanaka said: "We are still a long way from finding cures or therapies from stem cells and we don't know what processes will be effective.
"But we are finally in a position to make patient-specific stem cells for therapies without fear of immune rejection."
Read more: http://www.mirror.co.uk/news/healthnews/2007/11/21/new-stem-cell-leap-89520-20138114/