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First, you've got Peter Parker's initial relationship with the symbiote, how he bonds with it and then rejects it. How he acquires the symbiote in the first place isn't an important part of the story, and can be rewritten with no problems; it could just as easily have hitched a ride on the Space Shuttle in orbit, or escaped from a government lab.
Then you've got the story of Eddie Brock: his vendetta against Spider-Man, how he encounters the symbiote and becomes Venom, etc. They're two different stories with different themes, and even though they're connected, I don't think you can squash them together into one movie and still do either of them justice.
BTW, personally I had pictured David Boreanaz (Angel) as Brock/Venom. Topher Grace is a good actor, but this part calls for someone who can do tall, dark, and brooding. Plus, Boreanaz has more fight-scene experience.
Grace is still a better choice than Alfred Molina was for Doc-Oc, of course.
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