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Nebraska Legislation targets fat-dissolving procedure

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flashl Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Jan-23-08 11:28 PM
Original message
Nebraska Legislation targets fat-dissolving procedure
Fat-dissolving procedure targeted for regulation

Doctors would be prohibited from administering certain substances aimed at dissolving fat under a bill introduced in the Nebraska Legislature.

A hearing is scheduled today on the proposal, Legislative Bill 713.

The bill would affect a procedure called lipodissolve, which is administered by injection. The bill says the substances including sodium deoxycholate could not be administered for dissolving fat unless part of clinical testing approved by the U.S. Food and Drug Administration.

The bill was introduced by State Sen. Rich Pahls of Omaha. Ron Schroeder, an aide to Pahls, said the senator introduced the bill because of concerns raised by Dr. Joel Schlessinger.

Schlessinger, an Omaha dermatologist and cosmetic surgeon, said there has not been enough research to show whether lipodissolve is safe and effective.

The FDA has not approved the combination of drugs used in the lipodissolve injections, said Susan Cruzan, an FDA spokeswoman. She said the FDA is looking into whether there are concerns over how the lipodissolve is affecting patients.

Omaha World Herald

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BadgerKid Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Jan-23-08 11:51 PM
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1. deoxycholate info

Sodium Deoxycholate is water soluble ionic detergent/bile salt commonly used in applications ranging from cell lysis (RIPA Buffer), liposome preparation, isolation of membrane proteins and lipids, preventing nonspecific binding in affinity chromatography and a cell culture media supplement.

Sodium Deoxycholate is the detergent recommended for stripping endotoxin (Lipopolysaccharide or LPS) from our Detoxi-Gel Endotoxin Removing Gel. Scientists using Detoxi-Gel Endotoxin Removing Gel will also use this detergent.Storage: -20°C (internal) for long term storage, shipped ambient.

* The effectiveness of a detergent in any application is dependent on the detergents concentration. Too much or too little detergent can often have a deleterious effect. It is recommended that you examine a variety of detergent concentrations in your application.
* At concentrations above 2 mM, cholate will form micelles having MW ~2000. The small size of these micelle allows them to be easily remove by dialysis or gel filtration if needed.
* Note: removal of a detergent from a protein solution my result in protein precipitation and/or aggregation.



Basically it sounds like the procedure involves injecting the detergent into fatty tissue, probably ultrasounding said fatty tissue. The the detergent makes the fat water-soluble, and then that mixture can be filtered/sucked out. Essentially, washing out your inside.

I could see this being used on subcutaneous fat deposits.
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flashl Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Jan-24-08 10:06 AM
Response to Reply #1
2. Thanks for the response.
I am going to go as scientific as I can get on this. Washing fat with detergent? Ewwwww.

Do you think it was a good move for the state legislature to act on this?

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Warpy Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Jan-24-08 10:32 AM
Response to Reply #2
3. I think it was a great move
because it sounds like the concentrations might be tricky to manage.

They'll want surgeons who have been adequately trained in using this stuff, not fly by nighters who got sick of real doctoring and just hung out a liposuction shingle.
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BadgerKid Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Jan-24-08 02:28 PM
Response to Reply #2
4. I agree. Probably a good move.
I'm agreeing with Warpy. Safety is a concern.

I misled myself (:spank:) with that excerpt I posted -- I read into it thinking that the deoxycholate would be sucked back out somehow, kind of like liposuction. The OP however doesn't say that, so the method seems distinct from standard liposuction, i.e., inject and forget about it. Pretty neat and easy, but I'd be concerned that (1) the chemical doesn't dissolve useful fat distributions, and (2) these solubilized fats could plug something up, perhaps playing a role like that of "bad" cholesterol.

Further down the road will be questions pertaining to how the patient should eat when on this treatment. I'm sure it will be the usual "don't eat more than you burn off". Easier said than done. :)
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